Question: What is Doxycycline?
Answer: It is an antibiotic from the tetracycline group. Well-known to everyone, the drug "tetracycline" is a natural substance formed in nature by a special kind of fungus. The active part of the tetracycline molecule is isolated and modified with the help of the most complex chemical synthesis, as a result, a fundamentally new biologically active substance is formed, a new antimicrobial preparation. Its therapeutic activity significantly exceeds the progenitor (natural tetracycline), chemical synthesis allows to achieve a high degree of purification of the drug and the appearance of new very useful properties. As a consequence of this – there are new opportunities for use and a significant reduction in adverse reactions - both toxic and allergic.
Q: On what microorganisms it has action and how Doxycycline work?
A: The quantity of bacteria, the growth of which is actively suppressed by doxycycline, is very large - it is not without reason that it is referred to the so-called wide-spectrum antibiotics. The value of such drugs in general is precisely that one and the same disease, for example pneumonia, can be caused by hundreds of very diverse bacteria. In a situation where the diagnosis is established and the causative agent is unknown, a wide range of action of doxycycline acquires special significance, repeatedly reducing the risk of medical mistake. At the same time, it is possible to give a very specific list of very well-known microbes that cause very serious diseases, but are "subordinate" to its action: staphylococcus and streptococcus, dysentery bacillus and salmonella, causative agents of gonorrhea and syphilis (gonococcus and pale spirochaete, respectively). In addition to bacteria (they were just listed above), the drug also acts on rickettsia - these are the causative agents of typhus, and on a very insidious microbe called mycoplasma. The ability to suppress the most active reproduction of chlamydia is of particular importance, given the rapidly growing number of patients with urogenital chlamydia.
In a simplified form - the drug penetrates the cell and breaks the synthesis of protein in it. The microbe loses its activity and the ability to reproduce, and, moreover, that it soon dies itself, but also becomes an easy prey to the cells of the human immune system.
Q: If the word "streptococcus" does not explain you anything what are the diseases treated with Doxycycline?
A: Rheumatism, angina, scarlet fever, erysipelas. Other names are pneumonia, bronchitis, pleurisy, urinary tract infections, furunculosis, otitis media, gastrointestinal infections, whooping cough, anthrax, plague, cholera and hundreds of other names. To recapitulate chlamydia, syphilis, gonorrhea - you cannot think up a concrete one.
Q: But microbes that are resistant to Doxycycline are certainly available?
A: A universal drug "from everything" has not yet been invented. It does not affect viruses or fungal infections. Therefore, it is useless to treat them, for example, influenza, chickenpox or thrush.
Q: What are the new very useful properties of Doxycycline?
A: Firstly, the spectrum of action is significantly expanded, secondly, the risk of allergic reactions is significantly less, thirdly, the absorption from the gastrointestinal tract is markedly accelerated, and the excretion is slowed down. As a result, the therapeutic concentration of Doxycycline in the blood after a single dose is kept from 18 to 24 hours! And this is very important, since it allows taking the drug only once a day. In principle, the likelihood of developing side effects, characteristic of tetracycline, decreases in several times.
Q: Can you tell the Doxycycline side effects in more detail?
A: Allergy is possible, but its risk, in comparison, for example, with antibiotics of the penicillin or cephalosporin group, is less than many times. Sometimes there are undesirable reactions from the gastrointestinal tract - nausea, abdominal pain, constipation and diarrhea.
Q: When I cannot take doxycycline?
A: It is not recommended at pregnancy, categorically it is forbidden for children less than 8 years and it is very undesirable up to 12 and, of course, in case of allergy.
Q: For how long and how to take it?
A: First of all you cannot drink milk and eat dairy products with all tetracyclines because of calcium difficultly soluble salts. Usually on the first day of treatment 200 mg of the drug are taken, and then - Doxycycline 100 mg, once a day. In very serious condition, or with pronounced reactions from the gastrointestinal tract, is administered intravenously drip. Duration of admission can be determined only by a doctor, for specific diseases, appropriate treatment regimens have been developed. At long reception there is a risk of development of a candidiasis of an intestine, in this case simultaneously with it is prescribed an antifungal preparation.